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      <ns0:subfield code="a">The striatum (neostriatum) is one of the principal constituents of the basal nuclei. It is a complex structure which consists of a dorsal and the ventral components. According to the spine distribution and their density, neurons of the human striatum can be classified into two main types: spiny and aspiny cells. Further classification recognizes two groups of spiny, and three groups of aspiny neurons. The goal of this study was to analyze different morphometric properties of the digital images of the group IV and group V aspiny neurons, from the dorsal striatum of both cerebral hemispheres. In this study, a total of 175 two-dimensional images of aspiny neurons were analyzed. Image reconstruction and measurement was performed with the specialized, public software Image J. Four parameters of standard fractal analysis were quantified from these binary images. In addition, five textural parameters were obtained by analyzing grayscale images of the entire neuron. Results of both analyses show that six of nine parameters differed between the group IV and group V aspiny neurons. Moreover, in both groups of neurons, one parameter of the fractal and three of the texture analyses differed between the putamen and the caudate nucleus neurons. Thus, this study corroborates previous classification of aspiny neurons. Although they belong to the same aspiny group, different type of cells can qualify nerve signals in their own way. Therefore, this study supports the hypothesis that neuronal morphology differences can reflect their functional diversity and their role in communication.</ns0:subfield>
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      <ns0:subfield code="a">Background/Objectives: Gamma knife radiosurgery (GKRS) is widely performed as an adjuvant management of patients with residual or recurrent pituitary adenoma (PA). However, the variability in the tumor volume response to GKRS emphasizes the need for reliable predictors of treatment outcomes. The application of radiomics, an analytical approach for quantitative imaging, remains unexplored in predicting treatment responses for PAs. This study aimed to pioneer the use of radiomic MRI analysis to predict the volumetric response of PA to GKRS. Methods: This retrospective observational cohort study involved 81 patients who underwent GKRS for PA. Pre-treatment 3-Tesla MRI scans were used to extract radiomic features capturing the intensity, shape, and texture of the tumors. Radiomic signatures were generated using the least absolute shrinkage and selection operator (LASSO) for feature selection, in conjunction with several classifiers: random forest, naïve Bayes, kNN, logistic regression, neural network, and SVM. Results: The models demonstrated predictive performance in the test folds, with AUC values ranging from 0.759 to 0.928 and R2 values between 0.272 and 0.665. Single-sequence T1w, dual-sequence T1w + CE-T1w, and multi-modality including clinicopathological (CP) parameters (CP + T1w + CE-T1w) achieved rather similar prognostic performance in the test folds, with respective AUCs of 0.928, 0.899, and 0.909. All these radiomics models significantly outperformed a benchmark model involving only CP features (AUC = 0.846). Conclusions: This study represents a radiomic analysis focused on predicting the volume response of PAs to GKRS to facilitate treatment individualization. The developed MRI-based radiomics models exhibited superior classification performance compared with the benchmark model composed solely of standard clinicopathological parameters.</ns0:subfield>
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